Neil Bowles, PhD

Select Biography

Academic appointment: Research Associate Professor of Pediatrics, University of Utah

Research interests: Etiologies and Pathogenesis of Viral Cardiomyopathies and Kawasaki Disease.  Genetic Basis of Congenital Heart Disease.

Outside interests: Family, skiing, hiking.

Education: B.Sc. Biochemistry:  Queen Elizabeth College, University of London, UK; Ph.D. Biochemistry: Charing Cross and Westminster Medical School, University of London, UK

Post-graduate training: University of Geneva, Switzerland; Baylor College of Medicine, Houston, Texas.

Selected Publications:

1. Bowles NE, Richardson PJ, Olsen EGJ, Archard LC. Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 1986;i:1120-1123.
2. Bowles NE, Kearney DL, Ni J, Perez-Atayde AR, Kline MW, Bricker JT, Ayres NA, Lipshultz SE, Shearer WT, Towbin JA. The detection of viral genomes in the myocardium of pediatric patients with advanced HIV disease. J Am Coll Cardiol 1999;34:857-865.
3. Bowles NE, Ni J, Marcus F, Towbin JA. Detection of Cardiotropic Viruses in the Myocardium of Patients with Arrhythmogenic Right Ventricular Dysplasia. J Am Coll Cardiol 2002:39;892-5.
4. Bowles NE, Fuentes-Garcia FJ, Makar KA, Li H,  Gibson J, Soto F, Schwimmbeck PL,  Schultheiss H-P, Pauschinger M . Analysis of the Coxsackievirus B-Adenovirus Receptor gene in patients with myocarditis or dilated cardiomyopathy. Mol Genet Metab  2002:77;257-9.
5. Bowles NE, Ni J, Kearney DL, Pauschinger M, Schultheiss H-P, McCarthy R, Hare J, Bricker JT, Bowles KR, Towbin JA. Detection of viruses in myocardial tissues by polymerase chain reaction: evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003:42;466-72.
6. Yang Z, McMahon CJ, Smith LR, Bersola J, Adesina AM, Breinholt JP, Kearney DL, Dreyer WJ, Denfield SW, Price JF, Grenier M, Kertesz NJ, Clunie SK, Fernbach SD, Southerm SF, Berger S, Towbin JA, Bowles, KR, Bowles NE. Danon Disease as an Underrecognized Cause of Hypertrophic Cardiomyopathy in Children. Circulation 2005:112;1612-7.
7. Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG. Toll-like receptors 3 is an essential component of the Innate Stress Response in Virus-Induced Cardiac Injury. Am J Physiol Heart Circ Physiol. 2007:292;H251-8.
8. Purevjav E, Nelson DP, Jimenez S, Kearney DL, Sanchez X, DeFreitas G, Carabello B, Taylor MD, Vatta M, Shearer WT, Towbin JA, Bowles NE. Myocardial Fas Ligand Expression increases Susceptibility to AZT-Induced Cardiomyopathy. Cardiovasc Toxicol  2007:7;255-63.
9. Breinholt JP, Vallejo JG. Gates CM, Clunie SK, Kearney DL, Dreyer WJ, Towbin, JA, Bowles NE. Myocardial Cytokine Transcription Does Not Correlate With Cellular Rejection In Children With Heart Transplants. JHLT. 2008:27;317–24.